Radiotherapy supports protective tumor-specific immunity

Radiotherapy supports protective tumor-specific immunity

Radiotherapy is an important therapeutic option for the treatment of cancer. Growing evidence indicates that, besides inducing an irreversible DNA damage, radiotherapy promotes tumor-specific immune response, which significantly contribute to therapeutic efficacy. We postulate that radiotherapy activates tumor-associated dendritic cells, thus changing the tolerogenic tumor environment into an i...

Deliver Protective Antitumor Immunity Tumor-Specific Tc1, But Not Tc2, Cells

Tumor-specific Tc1, but not Tc2, cells deliver protective antitumor immunity.

We investigated whether secretion of multiple cytokines by CD8+ T cells is associated with improved protection against tumor challenge. We show that antitumor immunity induced by immunization with dendritic cells and a MHC class I-binding tumor peptide are dependent on secretion of IFN-gamma but not IL-4 or IL-5 by host cells. To further address the role of IL-4 and IL-5 in antitumor immunity, ...

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity

Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histoco...

Brief Definitive Report Peptide-pulsed Dendritic Cells Induce Antigen-specific, CTL-mediated Protective Tumor Immunity

Cytotoxic T lymphocytes (CTLs) are a critical component o f the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential imrnunogens for the induction o f specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable o f priming CTL responses in vivo. Here we show that major his...